Dianas: MTX5 & MTX3

Oncomatryx desarrolla precision drugs que apuntan a las células del estroma.

MTX5:

  • Membrane glycoprotein of cancer-associated fibroblasts
    Target MTX5 MTX3
  • Internalization capability
  • Peritumoral stroma overexpression in >90% carcinomas
  • No MTX5 gene expression has been reported in healthy tissues, with the exception of low-level expression in adipocytes, smooth muscle, bone marrow and uterus
  • Extracellular matrix remodeling, tumor growth and metastasis
  • Tumor immune system suppression. Depletion of MTX5-expressing cells in pancreatic cancer allowed TNF-α and IFN-ƴ immunological control of tumor growth. Depletion of MTX5-expressing CAFs overcame the lack of anti-tumor response of PD-L1 antibodies, and thus synergizing with anti-PD-L1 immunotherapy in pancreatic cancer.
  • Previous approaches blocking MTX5, have failed in Phase II due to lack of efficacy. Oncomatryx approach is not aimed at blocking MTX5, but at using MTX5 as a CAF-specific internalization vehicle for cytotoxic molecules.

 

MTX3:

  • Membrane protein of endothelial cells
  • Internalization capability
  • TGF-beta receptor pathway
  • Overexpression in tumor microvasculature cells
  • Low levels of MTX3 gene expression have been reported in cardiomyocytes and lung
  • Optimal accessibility from blood
  • Angiogenesis and neovascularization in different types of cancer

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