{"id":1917,"date":"2015-07-29T19:16:27","date_gmt":"2015-06-11T12:32:39","guid":{"rendered":"http:\/\/oncomatryx.com\/?p=1078"},"modified":"2015-07-29T19:16:27","modified_gmt":"2015-06-11T12:32:39","slug":"tumor-microenvironment","status":"publish","type":"post","link":"https:\/\/oncomatryx.com\/es\/tumor-microenvironment\/","title":{"rendered":"Tumor microenvironment:  A cancer key player to be fired"},"content":{"rendered":"<h5><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-1058 aligncenter\" src=\"http:\/\/oncomatryx.com\/wp-content\/uploads\/2015\/06\/stroma01b.jpg\" alt=\"Tumor microenvironment\" width=\"1000\" height=\"338\" \/><\/h5>\n<pre><\/pre>\n<h1><span style=\"color: #99ccff;\">Tumor microenvironment:<strong> A cancer key player to be fired<\/strong><\/span><\/h1>\n<h5>Novel precision drugs that target the tumor microenvironment are entering the battlefield against cancer.<\/h5>\n<p>Recent advances in the prevention and treatment of early stages of cancer have\u00a0achieved significant success. However, little progress has been made in the\u00a0development of new methods to fight late and invasive stages of cancer.<\/p>\n<p>Targeting the epithelial tumor cells, the tumor itself, with novel and innovative drugs\u00a0has rendered poor results to cure or even delay these devastating invasive cancer\u00a0stages.<\/p>\n<p>Broadening the scope of the battle field, revealed the overexpression of several\u00a0genes and proteins in patients with pancreatic ductal adenocarcinoma, infiltrating\u00a0breast adenocarcinoma, and other invasive carcinomas with a lethal prognosis. But\u00a0these genes and proteins were not expressed in the epithelial tumor cells, but in the\u00a0microenvironment that surounds the tumor.<\/p>\n<p>This peritumoral microenvironment, the tumor stroma, is a complex, heterogeneous\u00a0network of extracelular matrix and cell components \u2013 fibroblasts, endothelial cells,\u00a0immune cells \u2013 which play a key role in the growth, invasion, vascularisation,\u00a0metastasis, immunosuppression and drug resistance.<\/p>\n<p>A novel therapeutic approach to invasive tumors is arising, based on the\u00a0development of novel precision drugs aimed at targets located in the peritumoral\u00a0stroma. A novel way to treat cancer, which seeks to attack not the tumor cells, but\u00a0the cells that facilitate tumor invasiveness, immunosuppression and drug\u00a0resistance.<\/p>\n<p>Powerful and specific recombinant human proteins, monoclonal antibodies and\u00a0antibody-drug conjugates, targeting endothelial cells, cancer-associated fibroblasts\u00a0and the extracelular matrix are under development by pioneering biopharma\u00a0companies.<\/p>\n<p>Precised companion diagnostic devices are also developed and validated for the\u00a0stratification of patients to be treated with the drugs under deveclopment.<\/p>\n<p>We envysion a new era where cancer in general and invasive tumors in particular\u00a0will be beaten with orchestrated combinations of precision drugs that target the\u00a0epitelial tumor cells, to block tumor growth and drugs that target the tumor\u00a0microenvironment, to block tumor invasion, angiogenesis, metastasis,\u00a0immunosupression and drug resistance.<\/p>\n<h5><strong>Winds of hope are coming for those millions of patients that are suffering pancreatic\u00a0cancer and other devastating invasive tumors. Blowing is not a powerful whistle any\u00a0longer but a smartly orchestrated symphony.<\/strong><\/h5>\n<p style=\"text-align: right;\"><strong><a href=\"http:\/\/oncomatryx.com\/leadership\/\">Oncomatryx Team post<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tumor microenvironment: A cancer key player to be fired Novel precision drugs that target the tumor microenvironment are entering the battlefield against cancer. Recent advances in the prevention and treatment of early stages of cancer have\u00a0achieved significant success. However, little progress has been made in the\u00a0development of new methods to fight late and invasive stages &#8230; <a title=\"Tumor microenvironment:  A cancer key player to be fired\" class=\"read-more\" href=\"https:\/\/oncomatryx.com\/es\/tumor-microenvironment\/\" aria-label=\"Leer m\u00e1s sobre Tumor microenvironment:  A cancer key player to be fired\">Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":3,"featured_media":1057,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[20],"tags":[],"class_list":["post-1917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oncomatryx-blog"],"_links":{"self":[{"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/posts\/1917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/comments?post=1917"}],"version-history":[{"count":0,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/posts\/1917\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/media?parent=1917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/categories?post=1917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/oncomatryx.com\/es\/wp-json\/wp\/v2\/tags?post=1917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}